Release date: 2007-11-08
For the first time, US scientists have revealed that human protein receptor structure beta blockers have been used in clinical practice for more than 40 years, but until now, scientists have finally completed a detailed three-dimensional structure of the molecular targets of these drugs, β2 adrenergic receptors. Figure. This is the first time scientists have truly recognized the structure of a class of important human proteins, G-protein coupled receptors (GPCRs). According to experts, this latest research is definitely a major advancement. Many laboratories around the world are trying to reveal the mystery of this human protein. The discovery of this important structure will lead the research in this field to a new level. Relevant research results were published in the recent online edition of Science.
GPCRs are membrane proteins that scientists are most difficult to handle, especially in their three-dimensional structure. Because they resist the crystals necessary to form structural measurements. In order to understand GPCR, researchers have overcome great scientific obstacles. The only successful previous one was to determine the structure of the visual pigment in the cow's eye, but it was easier compared to the new study because the pigment protein is very rich, and one of the main challenges of the new study is to obtain enough β2 adrenergic receptors. protein.
After a lot of attempts at the natural crystalline morphology of the protein, researchers began turning to protein engineering to find a solution. To overcome the problem of protein softness, the researchers used an elastic ring with a harder protein structure and then induced the "stubborn" by mimicking the natural membrane morphology of the protein and setting the appropriate technical and environmental conditions. The protein becomes a fine crystal.
GPCR controls the body's key body functions, such as some of the human body's feelings. It also determines the role of nearly half of the drugs today. Therefore, this research can not only accelerate the research of new or improved drugs, but also broaden human understanding of their own health and disease. Experts say that these genetic engineering and crystallization techniques are widely applicable to similar proteins, paving the way for cracking hundreds of GPCR structures in human genome sequence maps. ——China Medicine 123 Network
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