The main route of virus infection of poultry is the respiratory tract, followed by the digestive tract. When the virion is in contact with the host cell, the biologically active HN protein recognizes and binds to the receptor site on the cell, causing the conformation of the self to change, thereby triggering the conformation of the F protein. This triggering mechanism may be the HN protein. The direct effect on the F protein may also be caused by the transmembrane signaling involved in cellular proteins. After the conformation of the F protein is changed, the internal fusion polypeptide is released to exert a transmembrane action, causing fusion of the viral envelope membrane with the cell membrane; or fusion of several cells to release the nucleocapsid into the cell, first utilizing its own RNA dependence The RNA polymerase catalyzes the synthesis of complementary positive-stranded RNAs, which are used as mRNAs to translate into proteins and transcribe viral genomes using cellular mechanisms. The synthesized Fo protein needs to be cleaved by host protease to n and F2. HN of certain strains also requires lysis. The synthesized viral protein is transported to the cell membrane, the cell membrane is modified, and the nucleocapsid is assembled near the modified region, and further sprouting causes the virus to be released. Viremia causes the virus to spread throughout the various organs of poultry, causing severe tissue damage through hemolysis, syncytium formation and cell destruction, and even widespread hemorrhagic lesions, leading to poultry death.
Slow-acting strains, such as Hitchner B1 (II line), F (III line) iLaSota (IV line), V4, Ulster 2C, D26 and its derivatives (clone 30, N79), etc., adult chickens generally do not develop i chicks may appear light Degree of respiratory symptoms, when extremely sensitive chicks encounter a slightly more virulent strain, occasionally death occurs. Such strains are often used as vaccines. Moderate strains, such as Mukteswar (1 line), Komarov, etc., have mild pathogenicity to adult chickens, can cause egg production to fall; can cause death in chicks. In our country, this strain is sometimes used to boost immunity; 'but it has been discontinued in most countries abroad. Rapid-type strains are classified into rapid-onset visceral (such as Herts'33/56) and rapid-onset neurotropic (such as TexasGB) according to tissue propensity. Acute infection can occur in all age-old chickens; fatal infections, clinical features of the former are mainly gastrointestinal bleeding, while the latter are mainly respiratory symptoms and neurological symptoms. Both medium and immediate strains can cause conjunctivitis in humans.
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Freeze Dried Fig
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