Release date: 2014-05-16
A few days ago, researchers at Yale University in the United States discovered that a substance produced by marine bacteria can kill cancer cells by destroying DNA. The new discovery paves the way for the development of low-dose chemotherapy drugs. Related papers were published in the May 11 issue of Nature and Chemistry.
The physicist organization network reported on May 13 (Beijing time) that the substance named lomaiviticin A has been previously proven to kill human tumor cells in culture dishes, but its mechanism of action has not been revealed for more than a decade. . In a series of experiments, Yale University scientists Seth Herzo, Peter Reiser and colleagues found that this substance can kill by etching, cutting and eventually destroying the DNA of cancer cells and blocking their replication process. cancer cell.
Herzo said that DNA is the target of many anticancer drugs, and DNA strands that directly destroy cancer cells are one of the most effective ways, but few anticancer drugs can directly cut DNA. Lomaiviticin A, produced by deep-sea bacteria, has this ability, and it is expected to be an effective chemotherapeutic drug, and it can be used in small doses.
This substance contains two diazoxides (functional groups that determine the chemical nature of the substance) and is closely involved in the entire process of DNA cleavage while shearing the standard DNA structure. For ease of understanding, you can compare lomaiviticin A to a pair of scissors, and DNA is the two vines that you want to trim. Just like cutting two vines, when they interact with DNA, they can simultaneously cut the two strands of DNA at one point.
This deep-sea bacterium also produces two other related substances, lomaiviticin C and kinamycin C, but both of them contain only one diazepine and cannot complete DNA cleavage.
Herzo said: "Although we don't know what kind of interaction between lomaiviticin A and DNA, and what ultimately leads to DNA breaks, one thing is clear: it is destroying cancer. The substance has a powerful ability on the DNA of the cell."
He added: "The previous six years of research have not found this ability. The significance of this work is to use synthetic chemistry and molecular biology to solve a problem that cannot be solved by any single discipline. Shows the tremendous power of interdisciplinary research."
Editor-in-chief
Many biologists believe that life originates in the deep sea; in the overflow energy of the submarine hydrothermal area, there is an older ecosystem than the current solar energy-dependent organism. In other words, deep-sea creatures are farthest from each other and most similar. Will the creatures that have passed through ancient times that have not yet evolved higher cells become an amazing killer? The medical potential of deep-sea creatures is therefore highly anticipated. If you find cancer specific drugs, deep sea sampling is the most scientific investment.
Source: China Science and Technology Network - Technology Daily
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