Release date: 2006-10-19
Recent research has highlighted the potential of lactic acid levels in tumors as a key indicator of radiation resistance. Scientists have proposed that the accumulation of lactate may be linked to metabolic processes, such as glycolysis or the intermediates involved in this pathway. One theory suggests that the ability of pyruvate to scavenge reactive oxygen species contributes to the resistance of malignant tumors to radiation therapy. To explore this, researchers transplanted five human head and neck squamous cell carcinoma (HNSCC) cell lines into nude mice and administered a radiotherapy regimen over six weeks, consisting of 30 treatments.
The study found that the radiation dose required to control 50% of the tumors (TCD50) varied widely, ranging from 47.4 to 129.8 Gy. To assess the metabolic activity within different tumor regions, researchers used structure-related quantitative bioluminescence imaging techniques to measure glucose, lactic acid, and ATP levels. The results showed that the average lactic acid concentration across the various cell lines ranged from 7.3 to 25.9 μmol/g. Notably, there was a strong positive correlation between tumor lactate levels and TCD50 values (R = 0.9824, p = 0.0028), supporting the hypothesis that higher lactic acid content is associated with greater radiation resistance.
These findings suggest that lactic acid levels could serve as a useful biomarker for predicting the response of solid tumors to radiation therapy. Furthermore, the study implies that temporarily inhibiting glycolysis during treatment might enhance the sensitivity of tumors to radiation, offering a potential strategy to improve therapeutic outcomes. This research opens new avenues for understanding the metabolic basis of radiation resistance and highlights the importance of targeting tumor metabolism in cancer treatment. (Medical Space)
Food Ingredient Fructo-Oligosaccharide,Organic Oligofructose GOS,Digestion Resistant Fiber
Qingdao Bailong Huichuang Bio-tech Co., Ltd. , https://www.sdblcycn.com