Release date: 2006-10-19
Recent studies have shown that the level of lactic acid in tumors may serve as a key indicator for predicting how resistant these tumors are to radiation therapy. Researchers believe that the accumulation of lactate could be linked to metabolic processes involving glycolysis or its intermediates. For example, the ability of pyruvate to scavenge free radicals might contribute to the resistance of malignant tumors to radiation. To test this idea, scientists transplanted five human head and neck squamous cell carcinoma (HNSCC) cell lines into nude mice and administered a radiotherapy protocol consisting of 30 sessions over six weeks.
The radiation dose required to control 50% of the tumors locally, known as TCD(50), varied widely among the different tumor models, ranging from 47.4 Gy to 129.8 Gy. To assess the metabolic activity within the tumors, researchers used structure-related quantitative bioluminescence imaging techniques to measure levels of glucose, lactic acid, and ATP in various regions of the tumors. The results revealed that the average lactic acid concentration across the different cell lines ranged from 7.3 to 25.9 μmol/g. Importantly, a strong positive correlation was observed between tumor lactate levels and TCD(50), with a correlation coefficient of R = 0.9824 and a p-value of 0.0028.
These findings support the hypothesis that lactic acid content in tissues is closely associated with the radiation resistance of human solid tumors. Moreover, the study suggests that measuring lactic acid levels in tumors could help predict their response to radiation therapy. It also raises the possibility that temporarily inhibiting glycolysis during treatment might enhance the sensitivity of tumors to radiation, potentially improving therapeutic outcomes. This research highlights the importance of understanding tumor metabolism in the context of cancer treatment strategies. (Medical Space)
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