The latest development of Parkinson's disease spinal cord treatment equipment in the United States

Release date: 2009-03-30


A few days ago, the latest issue of Science reported that the spinal cord electronic devices developed by American scientists could help rats with Parkinson's disease to become more active. The device is expected to treat Parkinson's disease in a less invasive way.

The team led by Mick Nicholelis, MD, of Duke University, conducted the study. The new technology transplants two extremely thin detectors into a small incision in the spine, allowing them to interact with the spinal cord. Intimate contact, then applying a current to it to deliver an electrical pulse that stimulates the peripheral nerves that transmit information between the brain and the body. Healthy human nerve cells "start" at different speeds, sending information between the brain and the body to exercise, while Parkinson's nerve cells are intermingled, suddenly "starting" at the same time, and producing dopamine (dopamine is associated with exercise) The brain cells are often "dead" and cannot produce the instructions that animals or people need for normal exercise. The current common treatment is to use dopamine replacement drugs to temporarily delay the symptoms, but not completely cure.

The researchers tested the device in mice with Parkinson's disease and also administered different doses of dopamine replacement drugs called levodopa. It was found that when the device was used together with the drug, only 2 drugs were needed to exercise the rats with Parkinson's disease; when using the drug alone, 5 drugs were needed to move the mice.

Levodopa will slowly lose its potency over time, and new equipment can prolong the time it takes for the drug to work. The researchers say the method is more effective than the currently implanted human brain technology, and it is easier to install stimuli in the spinal cord than in the brain. The research team plans to test the device on primates this year and hopes to apply it to humans in 2010.

Parkinson's disease affects approximately 1.5 million Americans and is a common central nervous system degenerative disease in middle-aged and elderly people. It is mainly characterized by slow patient movements, tremors in the hands and feet or other parts of the body, loss of softness in the body, and muscle stiffness. It is second only to tumors, cardiovascular and cerebrovascular diseases, and is called the “third killer” and “chronic cancer” of middle-aged and elderly people.
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