Common problems and causes in single-pressing tablet press--loose
Pine flakes mean that although the pressure is large, the tablet has a small hardness and is loose and brittle; some tablets have a certain hardness when they are initially pressed, but become loose after being placed. Reasons for pine slices:
(1) The compression molding property of the original and auxiliary materials is not good as described above. For example, the raw materials and auxiliary materials have strong elasticity. For example, the powder of Chinese herbal medicine contains cellulose and yeast powder, etc., although it can be molded under large pressure, once When placed, it is easy to loosen and loosen. In this case, it is necessary to add more plastic excipients in the prescription, such as compressible starch, microcrystalline cellulose, lactose, etc.; more excellent adhesives such as HPMC may also be used. The elasticity of the raw material is also related to the crystalline state, and if necessary, pulverization, for example, needle-like or flaky crystals are not easily tableted.
(2) Influence of water content The granules of the tablet should generally have a suitable water content. The overdried granules are not easily pressed into qualified tablets. When the original and auxiliary materials are completely dry, the elasticity is large, and the amount of water is moderate. It can enhance its plasticity; the particles have the right amount of water, and the effect of reducing the friction between the particles during compression can improve the transmission and distribution of the force. For example, when the tablet is compressed with sodium chloride, the water content is large and the pushing force is small. The opposite is big. In addition, the water content facilitates the formation of a solid bridge, which is advantageous for increasing the hardness of the tablet.
(3) Effects of Lubricating Agents Magnesium stearate is a commonly used lubricant in domestic Zui, but this product has adverse effects on the hardness of some tablets. For example, a lubricant such as magnesium stearate is added to the sulfathiazole tablet to the hardness thereof. The adverse effects are extremely significant.
(4) Compression conditions The pressure is closely related to the hardness of the tablet, and the compression time is also important. The development of plastic deformation requires a certain amount of time. For example, the compression speed is too fast, and the tendency of the plastic deformation of the material with strong plasticity will also increase, making it easy to loosen the sheet. The pre-pressing device is added to the tablet press to facilitate the pressing. Some people have designed a two-compression tablet press, and then increase the area of ​​the top of the punch of the rotary tablet press to increase the compression time.
(5) Other particle sizes such as original and auxiliary; selection of other auxiliary materials; and melting point of auxiliary materials also have influence.
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