Scorpion venom is a chronic disease characterized by central nervous system lesions caused by prion protein (PrP). The common features are chronic degenerative diseases of the central nervous system; clinical symptoms are mainly dementia, ataxia, and tremor.
[Etiology] Osmium is a protein particle, a non-cell type organism, which can pass through a bacterial filter with a molecular weight of 33-35 kD. Both human and animal PrP are encoded by a single copy gene on the host chromosome, human PrP. The gene is located on the short arm of chromosome 20, and the mouse PrP gene is located on chromosome 2. Recent studies have found that two isoforms of PrP, PrPc and PrPsc, can be isolated from the brain of diseased animals. PrPc is a glycoprotein that is unclear in normal brain tissue and is sensitive to proteases and does not cause disease. PrPsc has a molecular weight of 27-30 kD and is resistant to proteases and is a pathogenic protein. The normal brain tissue is only PrPc, and the brain tissue of the diseased animal has both PrPc and PrPsc.
[laboratory diagnosis]
1. Specific examination (1) cerebrospinal fluid 14-3-3 protein detection.
(2) Immunohistochemistry techniques.
(3) Western blotting technique to detect PrPsc protein.
2. Non-specific examination of cerebrospinal fluid routine examination.
[Result analysis and judgment]
1. Cerebrospinal fluid 14-3-3 protein detection has shown that the determination of cerebrospinal fluid 14-3-3 protein, the diagnostic rate of the disease can reach 92%.
2. Immunohistochemical examination The presence of PrPsc by immunohistochemical staining is currently considered the gold standard for the diagnosis of prion diseases.
3. Western blotting technology uses protein immunoblotting to directly determine the presence of PrPsc protein, positive for diagnosis.
4. Cerebrospinal fluid routine examination of patients with cerebrospinal fluid routine examination protein may be slightly elevated, other normal.
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