Release date: 2007-10-18
Anticardiolipin antibodies (ACA) have been linked to the immune mechanisms involved in Hemorrhagic Fever with Renal Syndrome (HFRS). HFRS is a serious infectious disease caused by hantaviruses, which are transmitted through rodents and lead to kidney damage. A study published in the Chinese Journal of Infectious Diseases in February examined the role of ACA in HFRS by comparing different patient groups.
The research team from the Second Military Hospital of the Chinese PLA, led by Hu Jinchuan, used ELISA to test for ACA-IgM and ACA-IgG in four groups: 54 HFRS patients, 52 lupus nephritis patients, 69 children with nephrotic syndrome, and 50 healthy controls. The results showed that none of the control group tested positive for either antibody. In contrast, 85.2% of HFRS patients were positive for ACA-IgM, and 24.1% for ACA-IgG. These rates were significantly higher than those seen in the other groups, with lupus nephritis patients showing 25.0% and 21.2%, respectively, and children with nephrotic syndrome at 13.0% and 8.7%.
The study found that the ACA-IgM positivity in HFRS patients was much higher compared to all other groups (P<0.01), while ACA-IgG levels were also significantly elevated compared to the control and nephrotic syndrome groups (P<0.05). These findings suggest that ACA may play a key role in the immune response and pathogenesis of HFRS. Further research is needed to explore the clinical implications of these antibodies in diagnosis and treatment.
— Midi Medical Network
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